BRAF and colorectal carcinoma: To extend our findings beyond BRAF-mutant CRC, we also characterised a previously established collection of RAS/BRAF WT cell lines, which were made resistant to the blockade of oncogenic kinases including anti EGFR antibodies and the NTRK inhibitor entrectinib (Fig. 1 and Supplementary Table 1)2,3,5–7,32.