In our study, PE led to significantly reduced levels of maternal HIF2α, IL-6 and IL-8, the later factor being both transcribed by HIF2α30, as well as significantly enhancing Int-6 serum concentrations, indicating, that at least in a L-NAME-induced rat PE model HIF2α signaling is changed systemically, while siRNA-Int6 reversed these changes partly and led to inhibition of hypertension and proteinuria in PE rats (Fig. 5). Here, EPAS1 is linked to Hypertension.