In addition, abnormalities grouped under the protein translation machinery pathway (e.g. MYC, EIF4A2), present in 9% of patients, were associated with a shorter OS (HR 4.9 95%CI 1.7–13.8, p = 0.003), as were abnormalities in tumor suppressor pathways (which includes TP53mut). The gene discussed is EIF4A2; the disease is neoplasm.