Although a 2-week administration of ghrelin did not change R6/2 mice body weight or their peripheral type 2 diabetes features38, this was sufficient to reverse the expression of catabolic genes (e.g. Caspase 8, Creb1 and Traf-5) and muscle morphology, as well as to rescue their nest building defects38. Here, CREB1 is linked to type 2 diabetes mellitus.