In the present study, liraglutide injected alone or together with ghrelin normalized peripheral basal glucose levels and both HOMA-β and HOMA-IR (two mathematical models widely used to evaluate β-cell function and insulin resistance, respectively, from fasting glycemia and insulin or C-peptide levels24,25) in R6/2 mice, suggesting a beneficial effect on glucose homeostasis, insulin resistance and pancreatic β-cell function. Here, INS is linked to Insulin resistance.