FANCM and male infertility: Because the patients declined to provide testicular tissues, and to understand whether the FANCM p.P648Lfs*16 PV is indeed the cause of male infertility, we generated a mouse model with a homozygous Fancm p.R638Rfs*8 PV (FancmΔC/ΔC) nearly equivalent to that in our patients (Supplementary Figure S5).