FANCM and Bone marrow hypocellularity: Similarly, increased tumorigenesis and cellular ICL sensitivity were also detected in Fancm knockout (Fancm∆2/∆2) mice, as well as FancmC4/C4 mice carrying a loss-of-function missense PV in the N-terminal helicase domain,18,19 while whether they would develop bone marrow failure was yet undetermined.