As a key scaffolding protein of the Wnt pathway, DVL in mammal consists of three highly similar homolog genes, DVL1, DVL2, and DVL3. Although DVL2 has received close attention in recent developmental studies due to its ubiquitous abundance in various tissues17–19, differential expression patterns of DVL homologs in human cancer have not been clearly determined20. Here, DVL2 is linked to cancer.