To further determine the effect of p53 on the co-activation of YAP and the Wnt pathway in clinical samples, we analyzed RNA expression data from primary human breast cancer (1093 samples from TCGA) and chose CTGF and Axin2 transcripts, which are representative target genes of YAP and TCF/LEF transcriptional machinery, respectively. The gene discussed is HNF4A; the disease is breast cancer.