When we analyzed the co-activation of YAP and the Wnt pathway in a patient cohort with respect to 20 years long-term survival, we found that increased abundance of CTGF and Axin2 was associated with worse prognosis in mutant p53 patients while the association was inverted in the wt p53 group (Fig. 6i), indicating the importance of p53 tumor suppressor context in co-activation of YAP and the canonical Wnt pathway in human cancer. This evidence concerns the gene CCN2 and cancer.