PLB1 and Hyperhidrosis: For the excessive sweating phenotype (hyperhidrosis), previous GWAS analyses have not been performed, and our current analysis implicated variants in one region that may regulate PLB1 and/or PPP1CB expression, and in another region, identified a known missense variant in ABCC11. An excessive rate of sweating may affect QOL in an individual’s social life, and therefore, cosmetic procedures to reduce hyperhidrosis has demand in the medical beauty-care industry.