Given that resveratrol, an indirect AMPK activator, was reported to exert its protective effects in association with increased expression of the AT2R and Mas receptors [42], further studies are required to determine whether AMPK has a role in activation of the ACE2-angiotensin-(1–7)-Mas receptor axis and AT2R to prevent hypertension, and whether this contributes to the reprogramming effects of AMPK activators. This evidence concerns the gene PRKAA2 and Hypertension.