Our previous work demonstrated that resveratrol, an AMPK activator, prevents the development of hypertension programmed by maternal plus post-weaning high-fructose diets, via regulation of nutrient-sensing signals [46], supporting the notion that nutrient-sensing signals might be a common mechanism underlying the pathogenesis of hypertension and kidney disease of developmental origin. This evidence concerns the gene PRKAA2 and hypertensive disorder.