In addition, another study reported that triple transgenic mice (3xTg-AD; 6 months old) exhibited lower myelin basic protein (MBP) expression and a smaller number of myelinating oligodendrocytes but a larger number of non-myelinating oligodendrocytes [89], indicating that AD pathology may impair the endogenous restorative responses in oligodendrocyte lineage cells. This evidence concerns the gene MBP and Alzheimer disease.