Contrary to this in various models of experimental cardiac hypertrophy, TNF inhibitor was able to reduce heart hypertrophy, which was believed to be mediated by a reduction of levels of myocardial hypertrophy marker genes, including atrial natriuretic factor (ANF), matrix metalloproteinase (MMP)-9, and MMP-13 [107]. This evidence concerns the gene TNF and cardiac hypertrophy.