PPARG and xeroderma pigmentosum group D: Lower S12ph/S21ph (together with decreased PPARγ phosphorylation, see below) is observed in Xeroderma pigmentosum group D (XPD) patients, which carry a mutation in the CDK7-containing Transcription factor II H (TFIIH) complex, and might partially explain their complex metabolic phenotypes, including reduced adipose mass and increased energy expenditure [14].