Ongoing clinical trials, including the PIONEER‐HF (Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT‐Pro‐BNP in Patients Stabilized From an Acute Heart Failure Episode) study9 and the TRANSITION (Comparison of Pre‐ and Post‐Discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event) study,10 will provide valuable information about the efficacy and safety of sacubitril/valsartan in patients with a recent episode of acute HF. The gene discussed is NPPB; the disease is heart failure.