Furthermore, we found that fibroblasts from the women with SUI exhibited significant decreases in the expression levels of TIMP-1, TIMP-2 and TIMP-3, while the mRNA expression levels of MMP-1, MMP-2, and MMP-9, which reportedly increase collagen degradation in stress incontinence, were significantly increased (Fig. 1h). This evidence concerns the gene TIMP3 and Stress urinary incontinence.