Furthermore, when the fibroblasts were treated with adMSC-conditioned medium, we found that the expression levels of TIMP-1 and TIMP-3 were significantly increased, while the mRNA expression levels of MMP-1 and MMP-2, which reportedly decrease collagen degradation in stress incontinence, were significantly decreased (Fig. 3c). The gene discussed is TIMP1; the disease is Stress urinary incontinence.