Taken together, HULC enhances autophagy in liver cancer cells via activating Sirt1.These data prove that HULC promotes the expression of LC3 not via Sirt1, and HULC increases the LC3II dependent on Sirt1.In particular, HULC promotes autophagy by enhancing the autophagy process of the transformation from LCI to LC3 II. The gene discussed is SIRT1; the disease is liver cancer.