MET and head and neck squamous cell carcinoma: Here, we have labeled the c-Met peptide (Met-pep1) with [18F]-NPFP and further evaluated the in vitro cell uptake, internalization, and efflux studies on UM-SCC-22B cells and in vivo distribution pattern and c-Met-targeting efficacy using microPET imaging in HNSCC xenograft-bearing mice.