FLCN and osteoporosis: To investigate the significance of metabolic reprogramming in osteoclast differentiation, we conditionally deleted Flcn by utilizing Mx1 promoter‐driven Cre transgenic mice.17Flcn knockout mice (Flcnf/f, Mx1‐cre) demonstrated severe osteoporosis with acute progression in 3 weeks after Flcn deletion induced by pIpC injection.