Pradhan et al. targeted IL-10 in DCs using siRNAs codelivered with adjuvant CpG (a TLR9 ligand) plus pDNA antigen, encoding the idiotype protein of A20 B cell lymphoma, associated with PLGA-PEI-derived microparticles [16]. The gene discussed is TLR9; the disease is B-cell non-Hodgkin lymphoma.