Previous study demonstrated that CIP2A protein was specifically expressed in cervical cancer tissues and was undetectable in normal adjacent cervical tissues.42 Our laboratory found that CIP2A protein was overexpressed in cervical cancer and high grade of cervical intraepithelial neoplasia (CIN), CIN III, which was the key step from the precancerous to invasive cancer, but not in normal cervical, CINI or CINII tissues.13 This expression pattern indicates that CIP2A has a clinical prominence in the development of cervical cancer and makes CIP2A to be a potential diagnostic biomarker. Here, CIP2A is linked to uterine cervix carcinoma in situ.