Neutrophil elastase is recognized to contribute to the development and progression of emphysema in humans and mice (Gardi et al., 1994; Cavarra et al., 2001; Tomashefski, 2008), but did not appear to be involved in CADM1 ectodomain shedding, according to the results of Figure 5. This evidence concerns the gene CADM1 and pulmonary emphysema.