In this study, we demonstrate the possibility of attenuating metastatic ability of two mouse mammary tumor cell lines, 4T1 (BALB/c background) and 6DT1 (FVB background) by targeting Cmas. Based on patient survival data, we are also optimistic about the potential of targeting CMAS in human cancer, especially since another study has already indicated that tumor growth is impacted by CMAS knockdown in human breast cancer cells (37). This evidence concerns the gene CMAS and cancer.