Over expression of MYC does not mean its uncontrolled expression but its persistent high expression which means that the expression level of MYC shows more fluctuations during a normal cell cycle in contrast to the tumor cells where its expression remains rather persistently high (compare the expression value in normal and chronic MYC during time frames 10–20, 30–40, 50–60 and 80–90). The gene discussed is MYC; the disease is neoplasm.