SnoN cooperates with the Hippo pathway to induce transformation and promote EMT of breast cancer cells.170 SnoN is also induced by TGF-β and prolactin via Stat5 in late pregnancy; thus, SnoN blocks TGF-β signaling and stabilizes STAT5 protein to activate the prolactin pathway in lactogenesis.112. Here, TGFB1 is linked to breast carcinoma.