SKI and lung carcinoma: Under this scenario, Ski fails to block TAZ activity and the proliferation of lung cancer cells.101 Moreover, one of the treatments to regulate Ski protein levels includes the use of the TGF-β inhibitory P144 peptide, which is derived from the extracellular sequence of the human TGF-β type III receptor, and interestingly, P144 promotes Ski downregulation in human glioblastoma cell lines, such as A172 and U-87 MG.286