Likewise, Ski-knockdown (KD) mice show defects in eye and neural tube formation.181Ski-KO mice mimic the same signs/symptoms of an anomaly named persistent hyperplastic primary vitreous (PHPV) observed in human and mouse models, which involves some ocular abnormalities, such as retinal malformations and microphtalmia.182 By contrast, overexpression of the Ski isoforms SkiA and SkiB gives rise to gastrulation alterations in zebrafish.94 The gene discussed is SKI; the disease is persistent hyperplastic primary vitreous.