RNA interference-mediated depletion of IFI16 or its presumed mouse ortholog p204 has revealed that both proteins are required for a functional IFN response to transfected dsDNA or infection with HSV-1 in various cell types, including human and mouse monocytic cell lines (134), mouse corneal epithelial cells (135), human primary and immortalized fibroblasts (136, 137), human primary macrophages (138), neutrophils (139), and dendritic cells (140). This evidence concerns the gene IFI16 and infection.