IQGAP1 and neoplasm: Using this “self” vs. “missing-self” model (Figure 3A), in vivo cytotoxic potential of Iqgap1−/− NK cells was determined through changes in the ratio of RMA/S to RMA tumor cells recovered from the spleens of tumor-bearing mice when compared with WT mice as well as those sufficiently depleted of NK cells (Figures 3B,C).