Still none of these above FHR studies have shown the direct role mouse FHR-A, FHR-B and FHR-C in mice with arthritis for FH−/− are resistance to CAIA and depletion of C3 in these mice occurs in FH−/− mice even in the presence of all mouse FHR proteins when there is no absolute competition. This evidence concerns the gene C3 and Arthritis.