FGF23 and hyperphosphatemia: Reaching serum levels of up to 1,000-fold higher than in healthy individuals, FGF23, and associated alterations in mineral metabolism, including hyperphosphatemia, hypercalcemia, secondary hyperparathyroidism, vitamin D, and klotho deficiency, are associated with uremic cardiomyopathy, LVH, premature death, and all cause mortality in CKD (35, 38, 41, 45–48).