Interestingly, Siah2-/- mice exhibited the same extent of cardiac hypertrophy estimated by LVW/BW compared to wt controls (Figure 5B), as well as similar deterioration of cardiac function investigated by means of FS% (Figure 5C), LVESd (Figure 5D), and LVEDd (Figure 5E). Here, SIAH2 is linked to cardiac hypertrophy.