The absence of Akap1 has been variously associated with increased ROS production and mitochondrial dysfunction in several models of cardio- and cerebrovascular diseases as well as in cancer (Feliciello et al., 1998; Scorziello et al., 2013; Schiattarella et al., 2016; Rinaldi et al., 2017). The gene discussed is AKAP1; the disease is cancer.