Adiponectin and adenosine monophosphate-activated protein kinase (AMPK) are associated with fatty acid oxidation in liver.(33) AMPK is activated by adiponectin signaling.(34) However, sterol regulatory element binding protein (SREBP)-1c enhances fatty acid synthesis.(35) Exercise decreases triglyceride synthesis by increasing adiponectin(36,37) and AMPK activation.(38) In addition, exercise also reduces SREBP-1c levels in liver.(39) Thus, exercise has a protective effect on fatty liver via activating the AMPK pathway and/or repressing the SREBP-1c pathway. This evidence concerns the gene ADIPOQ and fatty liver disease.