OGT has been documented to regulate the transcriptional machinery by modifying the many transcription factors involved in cancer-related processes.(12) Notably, O-GlcNAc levels are significantly elevated in various cancer types, including those of the breast,(13) prostate,(14) colon,(15) lung,(16) pancreas(17) and chronic lymphocytic leukemia.(18) Studies of in vivo xenografts of breast,(19) prostate(14) and pancreatic cancers(17) have shown a critical role for O-GlcNAcylation in tumorigenesis or metastasis. The gene discussed is OGT; the disease is cancer.