In Asians, the genetic loci most strongly attributed to AMD development are the Complement Factor H (CFH) gene and Age-related Macular Susceptibility 2 (ARMS2) / High-temperature requirement A-1 (HTRA1) loci as reported in the Genetics in AMD in Asians (GAMA) consortium43. The gene discussed is CFH; the disease is age-related macular degeneration.