CDH1 and cancer: Indeed, intact E-cadherin may be more advantageous compared with the soluble protein as the exosomal membrane, which is rich in cholesterol and sphingomyelin, helps to maintain a stable conformation of the cell surface protein for a half-life that is much longer (in some cases it can be as long as 90 days) compared to the soluble protein (from minutes to hours), thus enabling it to travel over long distance and displays significantly more effective cancer phenomena31,32.