Our results also confirmed the association of variants with POAG in 14 previously reported loci, including TGFBR3, TMCO1, AFAP1, FOXC1, GMDS, CDKN1A, CAV1/CAV2, CDKN2B-AS1, ABCA1, ARHGEF12, ATXN2, SIX1/SIX6, GAS7, and TXNRD2. The gene discussed is GMDS; the disease is open-angle glaucoma.