SIX1 and open-angle glaucoma: In the NTG analysis, of our 12 lead SNPs, 3 were associated at a Bonferroni level of significance and each had more extreme odds ratios in comparison to their association in the POAG GWAS: rs6913530 near CDKN1A; rs10811645 at CDKN2B-AS1; and rs35155027 in SIX1-SIX6 (Supplementary Table 5).