TMTC2 and open-angle glaucoma: Our study also identified a new region on chromosome 12 associated with POAG, near TMTC2. The TMTC2 locus has been previously reported to be associated with POAG in a Japanese population51, with a different lead SNP (rs7961953), however, this association did not reach a genome-wide level of significance, possibly due to limited sample size (total of 827 Japanese POAG patients and 748 control subjects without glaucoma)51.