SIX1 and open-angle glaucoma: We identified 3 additional SNPs with Bonferroni-level evidence of association with POAG that appeared to be independent of the lead SNP signals (P < 0.0001) at 3 loci (UCK2 on chromosome 1 (near TMCO1), CDKN2B-AS1 on chromosome 9, and near SIX1 on chromosome 14) (Supplementary Table 4).