USP9X and neoplasm: While the E3 ligase complexes SCFβ-TRCP and SCFFBXW7 have been shown to ubiquitinate YAP leading to its degradation18,26,27, USP9X, the only reported YAP DUB, was recently shown to promote tumor cell survival and chemoresistance through deubiquitination and stabilization of YAP50.