CXCL16 and pancreatitis: This hypothesis was further supported by the results of our analysis of Cxcl16−/− mice, showing that Cxcl16−/− mice were resistant to the development of acinar cell necrosis on day 2 as compared with Cxcl16-intact mice, whereas the sensitivity to the induction of edematous pancreatitis on day 1 was comparable between both strains.