PTGS2 and bronchiolitis obliterans syndrome: We discovered that lumen distention in BO leads to mechano-transcription of COX-2 and other pro-inflammatory mediators in gut smooth muscle18,31,38,39, and that the mechanical stress-induced COX-2 plays a critical role in the suppression of muscle contractility and motility function during the course of BO18,20,38,39.