Moreover, we demonstrated that BHCP exerts an inhibitory effect on melanogenesis and wrinkles that is associated with the downregulation of CREB/MITF/tyrosinase in α-MSH-induced B16F10 mouse melanoma cells and inhibition of phosphorylation of p65 and MMP expression in UV-induced Hs27 human fibroblasts. Here, CREB1 is linked to melanoma.