Of particular relevance to this report, T lymphocytes deficient for Diacylglycerol kinases DGK-ζ (known to play a role in TCR signal transduction by initiating degradation of the second messenger DAG) and engineered to express a cancer targeting chimeric antigen receptor (CAR) were less sensitive to TGF-β mediated suppression than their wild type counterparts [68]. Here, TGFB1 is linked to cancer.