STAT3 and Patent ductus arteriosus: Napabucasin (BBI-608, Boston Biomedical Inc., Boston, MA, USA) an orally available first-in-class cancer stem cell inhibitor that appears to target and inhibit gene transcription induced by STAT3 and cancer cell stem cell properties, demonstrated the ability to inhibit relapse in PaCa-2 PDA xenograft mouse models [75].