A study in patients with polycystic ovary syndrome (PCOS) described positive correlations between phoenixin-14 and LH, follicle-stimulating hormone (FSH), total testosterone, body mass index (BMI), and nesfatin-1 concentrations, and negative correlations with estradiol (E2) and fasting serum insulin [40]. This evidence concerns the gene NUCB2 and polycystic ovary syndrome.