HMOX1 and systemic lupus erythematosus: In a pristane-induced systemic lupus erythematosus (SLE) mice model, administration of EVOO containing high levels of phenolic compounds (600 ppm) reduced renal damage and MMP-3 serum and PGE2 levels in the kidney, as well as proinflammatory cytokine production in splenocytes, while up-regulating Nrf-2 and HO-1 protein expression and the activation of JAK/STAT, MAPK, and NF-κB pathways [191].