INS and metabolic dysfunction-associated steatotic liver disease: Moreover, in male Sprague–Dawley rats, a biophenol-rich VOO (0.290 mg phenols/kg/day) was able to (as compared to a phenol-free olive oil), significantly reduce liver inflammation and mitochondrial oxidative stress and restore insulin sensitivity, while limiting HFD-induced insulin resistance, inflammation, and hepatic oxidative stress, preventing nonalcoholic fatty liver disease (NAFLD) progression [153].