Finally, in amyotrophic lateral sclerosis (ALS) models, in vivo exposure to EVOO phenols resulted in higher survival and better motor performance, with improved muscle status and autophagy markers, and diminished endoplasmic reticulum (ER) stress [120], while in vitro it protected motoneurons from LPS-induced lethality, and inhibited IL-1β and NO release [121]. Here, IL1B is linked to amyotrophic lateral sclerosis.