When cell proliferation is suppressed, the inhibition of NF-κB genes in cancer cells occurs, followed by the downregulation of the vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9); MMP-9 aids in the degradation of the extracellular matrix of blood vessels and thus, reduces the rate of cancer cell invasion and migration [191,192,193]. The gene discussed is NFKB1; the disease is cancer.