MMP9 and neoplasm: Based on the fact that MMP-9 and MMP-2 are crucial factors for tumor migration and metastasis, we therefore performed wound healing assay to examine cell migration and found that cells treated with KP at 0.01, 0.05, and 0.1 mg/mL effectively reduced the percent of cell migration to 58.30 ± 5.8, 52.91 ± 5.32, and 40.50 ± 9.27%, respectively (Fig. 4a and b).