Primary FTLD-tauopathies show a wide range of astroglial tau immunoreactive morphologies, such as tufted astrocytes in progressive supranuclear palsy (PSP), astrocytic plaques in corticobasal degeneration (CBD), ramified astrocytes in Pick’s disease (PiD) or globular astroglial inclusions in globular glial tauopathies (GGT) [22, 28]. The gene discussed is MAPT; the disease is frontotemporal dementia.