In this cohort, only four patients achieved a complete or partial remission, with no details about whether the response was better in the tumoral syndrome (four had evaluable lymphadenopathy) or in monoclonal immunoglobulin and its hyperviscosity (five had measurable serum monoclonal IgM with symptomatic hyperviscosity or clinically relevant cytopenias). The gene discussed is CD40LG; the disease is Lymphadenopathy.