MCL1 and plasma cell myeloma: The researchers focused on frequent loss of the 1p12-21 region containing miR-137/miR-197 genes and demonstrated reduction of Mcl-1 protein and induction of apoptosis upon transfection of miR-137/miR-197 into myeloma cells as well as in vivo tumor regression by intratumoral injection of miR-137/miR-197 in a xenograft murine model of myeloma.