In the present study, we observed that (1) miR-197 expression levels were significantly low in the DLBCL progression group, (2) low miR-197 levels were associated with shorter PFS in the R-CHOP cohort and ABC subgroup, and (3) miR-197 enhanced doxorubicin sensitivity in SUDHL9 cells of the ABC subtype. Here, DDIT3 is linked to diffuse large B-cell lymphoma.