ABC DLBCLs are thought to be derived from B cells at a plasmablastic stage frequently expressing genes of mature plasma cells [49, 50] and exhibit CBM complex (CARD11, BCL10, and MALT1)-driven constitutive activation of NF-κB signaling [51, 52], which is a key oncogenic signaling pathway that activates Mcl-1 in multiple myeloma [53]. The gene discussed is NFKB1; the disease is plasma cell myeloma.