Xp11.2 translocation/TFE3 gene fusions renal cell carcinoma (Xp11.2 tRCC) was first listed as a new type of renal cell carcinoma (RCC) in the 2004 by the World Health Organization (WHO). This evidence concerns the gene TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.