Overall, relatively high NLRs, CRP/Alb ratios and PLRs were associated with a poor prognosis of Xp11.2 tRCC patients; among of them, only the NLR independently predicted the progression of Xp11.2 tRCC, and the NLR may help to identify patients with high metastasis or relapse risk. The gene discussed is CRP; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.