These clinical data further demonstrate that post-radiation PSA kinetics could significantly predict survival outcomes in cases with localized, high-risk disease; specifically, PSA nadir ≤ 1 ng/mL, time to PSA nadir ≤ 3 months, PSA doubling time > 12 months, and PSA reduction ≥ 90% were associated with improved tumor control. The gene discussed is KLK3; the disease is neoplasm.