KLK3 and posterior cortical atrophy: Thorsten et al. reported a discrepant conclusion regarding the predictive value of PSA for the biochemical control rate in 79 cases with high-risk PCa administered HDR-BT following EBRT, with an average follow-up of 21 months; the authors described PSA as a negative predictive biomarker for local recurrence during follow-up, indicating that prolonged follow-up is required for reassessing long-term outcomes [30].