In addition, some clinical trials found that a PSA nadir of less than 0.02 ng/mL within 12 months of radiotherapy is associated with significantly improved biochemical tumor control and cause-specific survival in cases of locally advanced and non-metastatic high-risk prostate cancer co-administered HDR-BT, EBRT, and long-term ADT [29]. This evidence concerns the gene KLK3 and Familial prostate cancer.