CDKN1A and prostate carcinoma: In a preclinical study with androgen-sensitive LnCaP and androgen-insensitive PC3 prostate carcinoma cells, Curcumin induced cell cycle arrest followed by the induction of apoptosis by cyclin-dependent kinase inhibitor (CIP) p21(WAF1/CIP1) (WAF1: wild-type p53-activated factor 1) [35].