Mutations in CHMP2B, (chromatin modifying protein 2B), FUS (fused in sarcoma), TARDBP (Transactive DNA-binding protein), VCP (Valosin containing protein), TBK-1 (TANK-binding kinase 1) have also been associated with FTD but are much rarer in incidence (Table 1). The gene discussed is TBK1; the disease is frontotemporal dementia.