SLC15A2 and Hyperglycemia: Here, in mice with overt hyperglycemia induced by streptozotocin (STZ) and exposed to dietary CAR supplementation, we analyzed the expression of a core gene network regulating CAR homeostasis (i.e., the genes coding for the Carns1 CAR synthase, Cndp1 and Cndp2 extra- and intracellular CAR dipeptidases, and the Slc15a2/Pept2 H+/oligopeptide transporter) and the presence of CAR content in the pancreas.